In vivo experiments provide valuable information of a molecule’s absorption, distribution, metabolism and excretion (ADME). ADME data is typically used to support an investigatory new drug (IND) application for subsequent clinical trials. Radiolabeled molecules used for biodistribution studies are currently the gold standard approach in the analysis of the pharmacokinetics and the quantification of relative tissue concentrations.
Positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging experiments using a radiolabeled molecule provide pharmacokinetic and pharmacodynamic (DMPK) pathways in real-time. PET images provide direct evidence at the site of action of target interaction and for occupancy measurements.Learn more about the Department of Medical Radiochemistry at HZDR